Hepatitis A Virus Incidence Rates and Biomarker Dynamics for Plasma Donors, United States

Abstract The United States is currently affected by widespread hepatitis A virus (HAV) outbreaks. We investigated HAV incidence rates among source plasma donors in the since 2016. Serial donations from HAV-positive frequent were analyzed for common biologic markers to obtain a detailed picture of course infection. found considerable increase with shifting outbreak hotspots over time. Although individual biomarker profiles highly variable, RNA typically had high peak and biphasic decrease often remained detectable several months. One donor pattern indicative previous exposure. Our findings show that current outbreaks have been spilling into population. results presented improve our comprehension infection related public health aspects. In addition, capture full curves enables estimation doubling